病毒性肝炎患者血清TNF-α，IL-6与肝纤维化指标关系的探讨

目的探讨病毒性肝炎患者血清TNF-α,IL-6及Ⅲ型胶原N端肽(PⅢNP)、Ⅳ型胶原(Col-Ⅳ)和透明质酸(HA)与肝纤维化的关系.方法采用ELISA检测患者血清TNF-α、IL-6、PⅢNP、Col-Ⅳ的含量;RIA检测HA的含量.结果病毒性肝炎患者血清中TNF-α和IL-6含量密切相关(r=0.658,P＜0.01),各肝炎组明显高于正常对照组(P＜0.01).TNF-α与IL-6,PⅢNP,Col-Ⅳ和HA呈显著正相关;IL-6与TNF-α,PⅢNP,Col-IV和HA呈显著正相关.除慢肝轻度组外,各肝炎组PⅢNP、Col-Ⅳ、HA含量均显著高于正常组(P＜0.01),且慢肝重度＞中度>轻度(P＜0.01).结论病毒性肝炎患者血清TNF-α和IL-6的含量能反映肝脏的炎症及纤维化程度,可作为判断病情及预后的参考指标.证实PⅢNP,Col-Ⅳ和HA均为反映肝脏炎症及纤维化的良好指标.