One-Pot Stereoselective Double Intramolecular Oxymercuration: Synthesis of Four Isomers of an Unsymmetrical Bis-Tetrahydrofuran Ring System

Stereoselective one-pot double intramolecular oxymercuration has been demonstrated to be the key reaction in the efficient preparation of the mono-hydroxylated bis-tetrahydrofuran ring system present in asimitrin and salzmanolin, two naturally occurring biologically active nonclassical acetogenins.