A kind of nadroparin calcium lyophilizing technique of low ethanol residual

The present invention proposes the nadroparin calcium lyophilizing technique of a kind of low ethanol residual, through freezing pre-treatment, pre-freeze, primary drying, parsing-desiccation, finally give nadroparin calcium, by the nadroparin calcium wet product that ethanol is precipitated, directly dissolve by purified water, carry out lyophilization, through the nadroparin calcium that lyophilizing technique is produced, Residual ethanol≤0.5%, meets the testing requirement to ethanol residual project in European Pharmacopoeia EP7.0.