Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea.

Bret Bannerman,Ling Xu,Matthew Jones,Christopher Tsu,Jie Yu,Paul Hales,Johan Monbaliu,Paul Fleming,Lawrence Dick,Mark Manfredi,Christopher F. Claiborne,Joseph B. Bolen,Erik Kupperman,Allison Berger

Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea.

2011

Bret Bannerman
Ling Xu
Matthew Jones
Christopher Tsu
Jie Yu
Paul Hales
Johan Monbaliu
Paul Fleming
Lawrence Dick
Mark Manfredi
Christopher F. Claiborne
Joseph B. Bolen
Erik Kupperman
Allison Berger

Purpose To investigate whether clinically relevant levels of epigallocatechin gallate (EGCG, a component of green tea) or vitamin C (ascorbic acid) could antagonize bortezomib antitumor activity in CWR22 human prostate xenograft tumors.

Keywords:

Antagonism
Epigallocatechin gallate
Biochemistry
Vitamin C
Bortezomib
Prostate
Pharmacology
Tandem mass spectrometry
Catechin
Chromatography liquid
Chemistry
ascorbic acid
tumor xenograft
antitumor activity
green tea

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