Regiospecific β-Lactam Ring-Opening/Recyclization Reactions of N-Aryl-3-spirocyclic-β-lactams Catalyzed by a Lewis—Broensted Acids Combined Superacid Catalyst System: A New Entry to 3-Spirocyclicquinolin-4(1H)-ones.

YinQiao Hu,Xiaolan Fu,Badru‐Deen Barry,Xihe Bi,Dewen Dong

Regiospecific β-Lactam Ring-Opening/Recyclization Reactions of N-Aryl-3-spirocyclic-β-lactams Catalyzed by a Lewis—Broensted Acids Combined Superacid Catalyst System: A New Entry to 3-Spirocyclicquinolin-4(1H)-ones.

2012

YinQiao Hu
Xiaolan Fu
Badru‐Deen Barry
Xihe Bi
Dewen Dong

The reduction of acetoacetanilides (I) followed by treatment of the intermediate alcohols with tosyl chloride gives rise to the desired 3-spirocyclic-β-lactams (II).

Keywords:

Superacid
Aryl
Tosyl chloride
Lactam
Catalysis
Organic chemistry
Chemistry
β lactams
system a

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