Effect of Compound Macro -stem Onion Capsule on the Expression of VCAM -1 and ICAM -1 in the Lung of Rat models with Pulmonary Hypertension

Objective: To explore the effect of compound Macro-stem Onion capsule on the expression of vascular cell adhesion molecule-1(VCAM-1) and intercellular cell adhesion molecule-1(ICAM-1) in the lung of rat models with pulmonary hypertension.Methods: SD rats were randomly divided into four groups including the normal control group,the model group,the high dose of compound Macro-stem Onion capsule group and the low dose of compound Macro-stem Onion group.Animal model of pulmonary hypertension was made by intra-peritoneal injection of wild lily alkali(MCT).2 days later,drug were given by intra-gastric injection.Average pulmonary arterial pressure(mPAP) and average right ventricular pressure and average(mRVP) were determined after 7 weeks.The expressions of VCAM-1 and ICAM-1 in the lung tissues were determined by immunohistochemical method.Results: Compared with the normal control group,the mPAP and mRVP of model group were obviously higher(P 0.01).The mPAP and the mRVP of high dose and low dose of compound Macro-stem Onion capsule groups were significantly higher than those of the normal control group and the lower than the model group.Compared with the normal control group,the expressions such as the VCAM-1 and the ICAM-1 of other groups were increased significantly.Compared with the model group,expressions including VCAM-1 and ICAM-1 of high dose of compound Macro-stem Onion capsule group were obviously decreased.The difference between the model group and the low dose of compound Macro-stem Onion group was not significant.Conclusion: The increases of VCAM-1 and ICAM-1 may be related with the formation of pulmonary arterial hypertension.Meanwhile,compound Macro-stem Onion capsule can effectively reduce pulmonary arterial pressure which may be associated with reduced expression of VCAM-1 and ICAM-1.