Investigation of the terminal P4 domain in a series of D-phenylglycinamide-based factor Xa inhibitors.

Abstract Several P4 domain derivatives of the general d -phenylglycinamide-based scaffold ( 2 ) were synthesized and evaluated for their ability to bind to the serine protease factor Xa. Some of the more potent compounds were evaluated for their anticoagulant effects in vitro. A select subset containing various P1 indole constructs was further evaluated for their pharmacokinetic properties after oral administration to rats.