Synthesis of N-(4-fluorophenyl)-1-(pyrrolidine-1-carbonyl) cyclopropane-1-carboxamide

In this work, a rapid and high yield synthetic method for N-(4-fluorophenyl)-1-(pyrrolidine-1-carbonyl) cyclopropane-1-carboxamide (8) was established. The target compound 8 was synthesized from the commercially available 1-(methoxycarbonyl) cyclopropane-1-carboxylic acid (5) via multi-step nucleophilic substitution reaction and ester hydrolysis. The structure of the target compound was confirmed by 1H NMR and MS spectrum. The total yield of the three steps was 48.8%.