Direct and Oxidant-Free Electron-Deficient Arylation of N-Acyl-Protected Tetrahydroisoquinolines
2016
A direct α-C–H electron-deficient arylation reaction of N-acyl protected tetrahydroisoquinolines is developed via visible light photoredox catalysis. The reaction was performed under mild conditions without any extra oxidant and could also proceed smoothly when sunlight was used as the light source. The protecting group on the tetrahydroisoquinolines could be removed easily.
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