Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m.

Sinar Sayed,Fatma M. Elsharkawy,Maha M. Amin,Hesham A. Shamsel-Din,Ahmed B. Ibrahim

Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m.

2021

Sinar Sayed
Fatma M. Elsharkawy
Maha M. Amin
Hesham A. Shamsel-Din
Ahmed B. Ibrahim

The research objective is to design intranasal (IN) brain targeted CLZ-loaded polymeric nanomicellar systems (PNMS) aiming to improve central systemic CLZ bioavailability. Direct equilibrium method...

Keywords:

Bioavailability
Technetium-99m
Pharmacology
Clozapine
Nasal administration
Chemistry
Micelle
brain targeting

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