Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase (HAT) Inhibitor

Jonathan E. Wilson,Gaurav Patel,Chirag Patel,François Brucelle,Annissa J. Huhn,Anna S. Gardberg,Florence Poy,Nico Cantone,Archana Bommi-Reddy,Robert J. Sims,Richard T. Cummings,Julian Levell

Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase (HAT) Inhibitor

2020

Jonathan E. Wilson
Gaurav Patel
Chirag Patel
François Brucelle
Annissa J. Huhn
Anna S. Gardberg
Florence Poy
Nico Cantone
Archana Bommi-Reddy
Robert J. Sims
Richard T. Cummings
Julian Levell

The histone acetyltransferases (HATs) EP300 and CBP are two highly homologous, multidomain, epigenetic coregulators that play central roles in transcription via acetylation of lysine residues on hi...

Keywords:

Biochemistry
Homologous chromosome
Biology
Lysine
Transcription (biology)
Acetylation
Epigenetics
Histone Acetyltransferases
Histone acetyltransferase
EP300

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