Novel N-sulfonylphthalimides: Efficient synthesis, X-ray characterization, spectral investigations, POM analyses, DFT computations and antibacterial activity

Abstract Some novel N-sulfonylphthalimides were synthesized in good yields by condensation of anhydride phthalic with various sulfonamides by two different methods: conventional synthesis and immersion ultrasonic assisted method, in one step. These compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus, Morganella morganii and Klebsiella pneumoniae.The bioinformatic POM analyses confirm the existence of a antifungal/or antiviral (O δ-----O δ-) pharmacophore sites. So it will benificial to test these molecules against other biotargets different of bacterial strains such as viruses, fungus and parasites.The molecular structure of 3a was obtained by X-ray diffraction on mono crystal. The crystal packing can be described as alternating layers in zigzag parallel to (100) plane along the c axis, which are connected together with C–H⋯O hydrogen bonds.