Positron Emission Tomography Imaging Evaluation of a Novel 18F-Labeled Sigma-1 Receptor Radioligand in Cynomolgus Monkeys.

Hongmei Jia,Zhengxin Cai,Daniel Holden,Yingfang He,Shu-fei Lin,Songye Li,Evan Baum,Anupama Shirali,Michael Kapinos,Hong Gao,Jim Ropchan,Yiyun Huang

Positron Emission Tomography Imaging Evaluation of a Novel 18F-Labeled Sigma-1 Receptor Radioligand in Cynomolgus Monkeys.

2020

Hongmei Jia
Zhengxin Cai
Daniel Holden
Yingfang He
Shu-fei Lin
Songye Li
Evan Baum
Anupama Shirali
Michael Kapinos
Hong Gao
Jim Ropchan
Yiyun Huang

We report a convenient radio-synthesis and the first positron emission tomography (PET) imaging evaluation of [18F]FBFP as a potent sigma-1 (σ1) receptor radioligand with advantageous characteristi...

Keywords:

Nuclear magnetic resonance
Sigma-1 receptor
Radioligand
Pharmacology
Positron emission tomography
Receptor
Chemistry

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