Influence of the aldehyde dehydrogenase 2 polymorphism on the vasodilatory effect of nitroglycerin in infants with congenital heart disease and pulmonary arterial hypertension

Tatsuya Nagano,Kentaro Ushijima,Naoyuki Taga,Mamoru Takeuchi,Masaaki Kawada,Kenichi Aizawa,Yasushi Imai,Akio Fujimura

Influence of the aldehyde dehydrogenase 2 polymorphism on the vasodilatory effect of nitroglycerin in infants with congenital heart disease and pulmonary arterial hypertension

2019

Tatsuya Nagano
Kentaro Ushijima
Naoyuki Taga
Mamoru Takeuchi
Masaaki Kawada
Kenichi Aizawa
Yasushi Imai
Akio Fujimura

Purpose The influence of the aldehyde dehydrogenase 2 (ALDH2) gene polymorphism on the pharmacokinetics and haemodynamics of nitroglycerin (GTN) was determined in human subjects.

Keywords:

Diabetes mellitus
Pulmonary hypertension
Anesthesia
Polymorphism (computer science)
Medicine
Aldehyde dehydrogenase
ALDH2
Gene polymorphism
Heart disease
Vasodilation
Cardiology
Internal medicine
Vascular resistance
Hemodynamics

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