Palladium-catalyzed oxidative aminocarbonylation of alkynone O-methyloximes with simple amines in PEG-400

2019 
A palladium-catalyzed oxidative aminocarbonylation of O- methyloximes and simple amines under aerobic conditions with PEG-400 as environmentally benign media was accomplished. This novel protocol provides the first straightforward synthetic method for the assembly of structurally diverse 4-carboxamide isoxazoles with high atom- and step-economy and exceptional functional group tolerance. Notably, the employment of ionic liquids as additive, with air as the sole oxidant, without ligands are some of the attractive features of the present approach.
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