A three-dimensional multipedal DNA walker for the ultrasensitive detection of tumor exosomes.

A three-dimensional (3D) multipedal DNA walker triggered by the specific recognition between aptamers and proteins was developed for ultrasensitive tumor exosome sensing. A detection limit of 1 particle μL−1 was obtained with high selectivity. With the advantages of being simple, cost-effective and ultrasensitive, the biosensor offers potential for the early clinical diagnosis of tumors.