Use of proteasome activity inhibitor PI in preparation of drug or health food for preventing and treating osteosarcoma

The invention belongs to the technical field of medicines and relates to a use of a proteasome activity inhibitor PI in preparation of a drug or a health food for preventing and treating osteosarcoma. An experiment result shows that the proteasome activity inhibitor PI has selective inhibition effects on proteasome chymotrypsin (CT)-type activity, the proteasome activity inhibitor PI can induce osteosarcoma apoptosis through inhibition of NF-kB pathway and activation of unfolded protein reaction (UPR)/endoplasmic reticulum (ER) stress signal cascade in osteosarcoma cells, the PI adjusts an osteosarcoma cell cycle and growth through decreasing of a c-Myc signal path and the PI reverses osteosarcoma cell EMT through decreasing of Vimentin, Snail and Slug and increasing of E-cadherin expression. The result shows that the PI can be used as a novel natural proteasome inhibitor, has a potential of osteosarcoma prevention and treatment and can be used for preparing a drug or a health food for preventing and treating idiopathic and secondary osteosarcoma.