Mathematical Optimization, the Effect of the Catalyst and Solvent on the Process of Starch Sulfation with Sulfamic Acid

Starch is one of the most common polysaccharides. The scope of its application is wide enough, and chemical modification expands them even more. In this work, the preparation of a biologically active starch derivative, sulfate, is considered. In addition, in this work, for the first time, the study of the effect of catalysts and solvents on the process of sulfation of starch with sulfamic acid. It was shown that the most effective catalyst is urea, and the solvent is DMSO. For this system “sulfamic acid-urea-DMSO” mathematical optimization was carried out. It is shown that the optimal conditions for obtaining starch sulfates, providing the maximum sulfur content in the resulting reaction product, are: temperature 87.1 °C and duration 2.7 h. The introduction of a sulfate group into a starch molecule was confirmed by elemental analysis and FTIR spectroscopy.