Relationship between Viral Propagation and Apoptosis after Marine Birnavirus (MABV) Infection

This study was performed to confirm the relationship between viral propagation and apoptosis by the infection of marine birnavirus strain (MABV NF-4) on chinook salmon embryo (CHSE-214) cells. After 6 hr viral infection, MABV was detected by PCR method. Also, as a result of DNA assay on the cells, MABV infection resulted in a typical feature of apoptosis, DNA fragmentation. The results suggest that MABV replicated to high concentrations during the early stage of infection induces apoptosis.