Cytoplasmic parafibromin/hCdc73 targets and destabilizes p53 mRNA to control p53-mediated apoptosis.

Mutations of hCdc73, a component of the PAFc complex that regulates RNA polymerase II-dependent transcription, have been associated with parathyroid carcinoma. Here the authors show that hCdc73 regulates the mRNA stability of p53 through the interaction with eEF1Bγ, a translation elongation complex subunit, and hSki8, a component of mRNA decay complex.