Tetrazole based amides as growth hormone secretagogues

James J. Li,Haixia Wang,Jun Li,Fucheng Qu,Stephen G. Swartz,Andres S. Hernandez,Scott A. Biller,Jeffrey A. Robl,Joseph A. Tino,Dorothy Slusarchyk,Ramakrishna Seethala,Paul G. Sleph,Mujing Yan,Gary J. Grover,Neil Flynn,Brian J. Murphy,David A. Gordon

Tetrazole based amides as growth hormone secretagogues

2008

James J. Li
Haixia Wang
Jun Li
Fucheng Qu
Stephen G. Swartz
Andres S. Hernandez
Scott A. Biller
Jeffrey A. Robl
Joseph A. Tino
Dorothy Slusarchyk
Ramakrishna Seethala
Paul G. Sleph
Mujing Yan
Gary J. Grover
Neil Flynn
Brian J. Murphy
David A. Gordon

A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.

Keywords:

Chemical synthesis
Hormone
In vivo
Biochemistry
Tetrazole
Organic chemistry
Amide
Somatotropin-releasing factor
Biological activity
Stereochemistry
Chemistry
In vitro
rat model
growth hormone

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