Interference of extraneous solutes in the iontophoresis of salicylic acid across the skin

It has been analyzed the possibility to modify the cutaneous ionthophoresis of drugs by means of an original apparatus through which experiments are performed on isolated rat skin. The test drug employed as the salicylic acid (SA). The presence of parasite ions decreases the passage of SA through the skin with an effect which is proportional to the salt concentration. The sodium salicylate is transferred less than SA. It has been analyzed the effect of drugs increasing the skin permeability like dimethylsulfoxide (DMSO) and dimethylformamide (DMF). DMSO in combination with SA facilitates the SA cutaneous ionthophoresis, while DMF does not.