Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases

Matthew J. Riese,Liang-Chuan S. Wang,Edmund Moon,Rohan P. Joshi,Anjana Ranganathan,Carl H. June,Gary A. Koretzky,Steven M. Albelda

Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases

2013

Matthew J. Riese
Liang-Chuan S. Wang
Edmund Moon
Rohan P. Joshi
Anjana Ranganathan
Carl H. June
Gary A. Koretzky
Steven M. Albelda

Targeting of diacylglycerol kinases offers a general approach to enhance the function of chimeric antigen receptor T cells (CART cells), a promising new strategy for cancer immunotherapy.

Keywords:

Cancer immunotherapy
Chimeric antigen receptor
Molecular biology
Cytotoxic T cell
Diacylglycerol kinase
Immunology
HEK 293 cells
Signal transduction
Effector
Kinase
Biology

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