Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints
2014
Background
Mitochondrial DNA (mtDNA) deletions cause disease and accumulate during aging, yet our understanding of the molecular mechanisms underlying their formation remains rudimentary. Guanine-quadruplex (GQ) DNA structures are associated with nuclear DNA instability in cancer; recent evidence indicates they can also form in mitochondrial nucleic acids, suggesting that these non-B DNA structures could be associated with mtDNA deletions. Currently, the multiple types of GQ sequences and their association with human mtDNA stability are unknown.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
68
References
70
Citations
NaN
KQI