Integrated optic surface plasmon resonance measurements in glass substrates
2007
The surface plasmon resonance (SPR) technique is an optical method that can be used to measure the refractive index of
organic nano-layers adsorbed on a thin metal film. Although there are many techniques for measuring biomolecular
interactions, SPR-based techniques play a central role in many current biosensing experiments, since they are most suited
to sensitive and quantitative kinetic measurements. Here we give some results from the analysis and numerical
elaboration of SPR data regarding the flow of different solutions with refractive indexes in the range of interest (1-1.4).
After a brief discussion of the principles of SPR and of waveguide fabrication technique, we give a description of
system setup and some results regarding the real time waveguide output intensity monitoring to measure the interaction
between the gold thin film and the analyte.
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