Effect of PPAR-γ2 gene Pro12Ala and ADR-β3 gene Trp64AArg polymorphism on glucose homeostasis in Type 2 diabetes subjects from Western India.

Materials and methods The present study comprises of 535 subjects (including 235 T2D & 300 controls). Genotyping was carried out for the above mentioned polymorphisms and glycosylated hemoglobin [HbA1C] levels were analyzed for each subject. All T2D subjects were divided into four groups according to their genotype. Group-I: 31 patients with Pro/Pro and Trp/Arg genotype; Group-II: 159 patients with Pro/Pro and Trp/Trp genotype; Group-III: 6 patients with Pro/Ala and Trp/Arg genotype; and Group-IV: 39 patients with Pro/Ala and Trp/Trp phenotype.