Ligand-Enabled Stereoselective β-C(sp3)–H Fluorination: Synthesis of Unnatural Enantiopure anti-β-Fluoro-α-amino Acids

A quinoline-based ligand was shown to promote palladium-catalyzed β-C(sp3)–H fluorination for the first time. A range of unnatural enantiopure fluorinated α-amino acids were obtained through sequential β-C(sp3)–H arylation and subsequent stereoselective fluorination from readily available l-alanine.