Neuroprotective effect of Nrf2/HO-1 signaling pathway in cerebral ischemia combined with diabetes mellitus

Glucagon and its analogues are a intestinal stimulating insulin screened by the small intestinal L cells. It can smoothly penetrate the blood-brain barrier into the brain tissue and play a neuroprotective role. Liraglutide and glucagon and its analogues have higher homology. After entering the brain tissue, it is able to bind with the related receptors and activates Nrf2/HO-1 signaling pathway and thus reducing the production of oxidative stress products, increases the glutathione, heme oxygen synthase, superoxide dismutase and other phase Ⅱ detoxification enzymes, promotes angiogenesis, and protects the nerve cells of diabetes combined with cerebral ischemia injury. Key words: Brain Ischemia; Diabetes Mellitus; NF-E2-Related Factor 2; Heme Oxygenase-1; Oxidative Stress; Glucagon-Like Peptide 1; Liraglutide; Neuroprotective Agents