Two new dimmeric xanthanolides isolated from Xanthium mogolium Kitag plant

Abstract Two xanthanolide-type dimmers, namely Mogolide D ( 4 ) and Mogolide E ( 5 ) are isolated from the aerial parts of Xanthium mogolium Kitag plant collected from Heilongjiang province, China. The dimmers’ relative structures are elucidated on the basis of HRESIMS, IR spectrum and NMR spectroscopy. The absolute configurations of them are assigned with ECD spectra. The biosynthetic pathway of the two dimmers is also proposed. Besides, Mogolide D ( 4 ) and Mogolide E ( 5 ) are tested against MDA-MB-231 breast cancer cell line with IC 50 8.46 μM and 19.20 μM, respectively.