Association between human SLC6A4 gene promoter polymorphism and the chinese people with antisocial personality disorder

Ninety chinese with APD and 140 chinese controls were examined: All subjects were evaluated by PDQ-4, then a diagnosis was made based on the DSM-IOV classiofications. The DNA fragments of SLC6A4 promoter region were measured using PCR assay, and verified by sequencing. Both allele frequencies and genotype frequencies in two groups were compared. The PCR products included three allele: L, S and XL, which composed of four genotypes: LL, LS, SS and ILL. The S allele frequence and SS genotype frequence in the APD were 61.8% and 37.08% respectively, which demonstrated a significant difference when compared with controls (P<0.005). These results suggested an associated between the S allele frequence and APD.