Stereoselective Syntheses of Di-, Tri-, and Tetrasubstituted Enediynes from Enynyl Iodides via Pd-Catalyzed Coupling Reactions.

Abstract Palladium catalyzed cross-coupling of iodoenynes derived from mono(stannyl)enynes with alkynyl zinc reagents affords isomerically pure conjugated di-, tri- and tetrasubstituted (Z)-enediynes and trisubstituted cross- conjugated enediynes in high yields.