Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6

The cytokine TGF-β signals through canonical, Smad-dependent, and non-canonical, Smad-independent pathways. Jung et al. show that Smad6, an inhibitor of canonical TGF-β signalling, also inhibits a non-canonical pathway by recruiting a deubiquitinase to TRAF6.