Radiobiology with laser-accelerated quasi-monoenergetic proton beams
2011
Human cancer cells are irradiated by laser-driven quasi-monoenergetic protons. Laser pulse intensities at the
5×10 19 -W/cm 2 level provide the source and acceleration field for protons that are subsequently transported by
four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66
MeV and a bunch duration of 20 ns. The survival fraction of in-vitro cells from a human salivary gland tumor
is measured with a colony formation assay following proton irradiation at dose levels up to 8 Gy, for which the
single bunch does rate is 1 × 10 7 Gy/s and the effective dose rate is 0.2 Gy/s for 1-Hz repetition of irradiation.
Relative biological effectiveness at the 10% survival fraction is measured to be 1.20 ± 0.11 using protons with a
linear energy transfer of 17.1 ± 2.8 keV/μm.
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