Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance

The authors performed a genome-wide RNAi screen for genes modifying mutant Huntingtin (mHTT) clearance, identifying NUB1 as a protein whose overexpression lowered mHTT protein amounts, rescued mHTT-induced neuronal death and improved motor function in a Drosophila model of Huntington's disease. NUB1 promoted polyubiquitination and proteasomal degradation of mHTT.