Study on Adulterate Sodium Silica Apatite Cement Porous Scaffolds for Bone Defect Repair

Adulterate sodium silicon apatite cement (s-AC) porous scaffolds for bone repair were prepared by us- ing the mixed powders of tetracalcium phosphate and dicalcium phosphate anhydrous, 5wt% sodium silicate water- solution as cement liquid, and NaCl particles as progens. The result shows that the composition of the s-AC scaf- folds is sodium silicon apatite. The macroporous sizes of the scaffolds were in the range from 200 μm to 600 μm, the porosity of the scaffolds is from 58% to 75%, and the macropores were interconnected with each other. The compressive strength of the s-AC scaffolds is from 1.6MPa to 3.8MPa, and the degradability of sodium silicon doped s-AC scaffolds improves significantly as compared with AC in Tris-HCl solution. When the s-AC scaffolds are implanted in femur bone defect of rabbits, the histological analysis results show that the new bone tissue is formed on the surfaces and ingrew into the interior of the scaffolds, the well interconnected macropores promoted the bone tissue ingrowth into the scaffolds. In conclusion, the s-AC scaffolds exhibit good biocompatibility, de- gradability and osteogenesis in vivo, which will be a good biomaterial for bone repair.