ANTISENSE PROPERTIES OF 2′-O-DIMETHYLAMINOOXYETHYL (2′-O-DMAOE) OLIGONUCLEOTIDES

Antisense oligonucleotides with 2′-O-{2-[N,N-dimethyl)aminooxy]ethyl} or (2′-O-DMAOE) modification were synthesized and evaluated for nuclease resistance and pharmacology both in vitro and in vivo. This modification exhibits very high nuclease resistance and efficacy in various biological (ICAM-1, C-raf and PKC-α) targets.