Bisphenol A induces protection through modulation of the immune response against the helminth parasite Taenia crassiceps.

2020 
AIMS: Industrial growth has increased the exposure to endocrine disruptor compounds (EDCs) in all organisms. Bisphenol A (BPA), an EDC, has been demonstrated to be involved in the susceptibility to parasite infections. However, few studies have analyzed this connection in more depth. The aim of this study was to determine if early BPA exposure in female mice affects the systemic immune response and the susceptibility to T. crassiceps infection. METHODS AND RESULTS: BALB/cice were exposed to BPA at postnatal day 3. At 6 weeks of age, they were inoculated with T. crassiceps larvae, and 2 weeks later, were euthanized. The number of parasites was quantified. By flow cytometry, in the spleen, the peripheral and mesenteric lymph nodes, the different innate and adaptive immune cell modulation was analyzed, and RT-PCR cytokine expression was also evaluated. BPA induced a reduction of 40% in parasite load. BPA treatment modulated some lineages of the innate immune response and caused slight changes in cells belonging to the adaptive immune response. Additionally, BPA enhanced the type 2 cytokine profile. CONCLUSION: Neonatal BPA treatment in female mice affects not only the percentage of different immune cells but also theirex vivo cytokine gene expression., decreasing T. crassiceps cysticercosis susceptibility.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    23
    References
    0
    Citations
    NaN
    KQI
    []