Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD + oscillation

The Intracellular levels of nicotinamide adenine dinucleotide (NAD + ) are rhythmic and controlled by the circadian clock. However, whether NAD + oscillation in turn contributes to circadian physiology is not fully understood. To address this question we analyzed mice mutated for the NAD + hydrolase CD38. We found that rhythmicity of NAD