Three Sickle Cell Anemia Patients Each with a Different α Chain Variant. Diagnostic Complications

We have studied three sickle cell anemia patients who also carried a heterozygosity for one of the following a chain abnormalities: Hb G-Philadelphia [α68(E17)Asn→Lys], Hb Montgomery [α 48 (CE6)Leu→Arg], and Hb Chicago [αl36(H19)Leu→Met]. Electrophoretic analyses alone may result in incomplete and incorrect information. Confirmation of the diagnosis of Hb SS or Hb SC disease by one of the fast high performance liquid chromatographic procedures is recommended.