Postantibiotic effect of norfloxacin and its influence on profiles of outer membrane proteins of Pseudomonas aeruginosa.

Norfloxacin at suprainhibitory concentrations induced postantibiotic effects (PAEs) in the range of 6h to 11.4h (2.MIC) and of 10.1 to more than 13.4 h (4.MIC) against three P.aeruginosa strains. After PAEs, the outer membrane profile proteins of the strains studied was changed. Overproduction of 41 kDa protein as well as strong reduction of 23 kDa and 45 kDa proteins were found in all three strains. A reduction of the protein band in the range of 35 kDa was also observed in all strains, but to a smaller extent