Synthesis of β-d-GalNAc(4,6-diS)(1–4)[α-l-Fuc(2,4-diS)(1–3)]-β-d-GlcA, a novel trisaccharide unit of chondroitin sulfate with a fucose branch
2013
Abstract Novel glycosaminoglycans isolated from the body wall of sea cucumbers consist of chondroitin sulfates like polysaccharides. We have synthesized a representative repeating trisaccharide composed of a chondroitin backbone having a fucose (Fuc) branch at O -3 of glucuronic acid (GlcA), β- d -GalNAc(4,6-diS)(1–4)[α- l -Fuc(2,4-diS)(1–3)]-β- d -GlcA, in a stereocontrolled manner. Regiospecific sulfation at O -4,6 and O -2,4 of the N -acetylgalactosamine (GalNAc) and Fuc residues, respectively, was successfully achieved.
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