The Preventive Effect of Rome Beauty Variety Apple Skin Extract on Blood Urea Nitrogen (BUN) levels of Rat (Rattus norvegicus) Induced by Lead (Pb)

Lead (Pb) is a heavy metal that can cause poisoning in living things. Pb contamination that enters the body through the digestive system will bind to erythrocytes and trigger an increase in ROS the body resulting in a decrease in organ function such as the kidneys followed by an increase in levels of BUN. Apple is an example of a fruit that rich in antioxidant. Apple skin contains flavonoids which act as antioxidants and as chelating agent for metal ion. The parameters observed in this study were BUN levels. This study consist of 5 groups with each group consisting of 4 white rats, namely negative control, positive control with 10 mg Pb / head / day of Pb administration for 14 days, and preventive therapy group with Rome Beauty apple skin extract 28 mg/200g, 56 mg/200g, and 112 mg/200g for 21 days and giving lead at a dose of 10 mg/rat/day for 14 days. BUN levels were analyzed using one way ANOVA method which was followed by Turkey. The results showed that the preventive group of apple skin extract of Rome Beauty variety with a dose of 112 mg/200g was able to prevent an increase in BUN levels.