A highly active organocatalyst for the asymmetric α-aminoxylation of aldehydes and α-hydroxylation of ketones
2012
Enantiopure trans-3-trifluoromethylsulfonylamino-4-silyloxypyrrolidines efficiently catalyse the asymmetric α-aminoxylation of aldehydes. At 1% catalyst loading (solvent-free conditions) or at 2% catalyst loading (acetonitrile solution) aldehydes are completely converted in short reaction times leading to α-aminoxylation products with very high (96–99%) enantioselectivity.
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