Effect of Renin-Angiotensin System Blockade on the Expression of the Angiotensinogen Gene and Induction of Hypertrophy in Rat Kidney Proximal Tubular Cells

Shao-Ling Zhang,Catherine To,Xing Chen,János G. Filep,Shiow-Shih Tang,Julie R. Ingelfinger,Serge Carrière,John S.D. Chan

Effect of Renin-Angiotensin System Blockade on the Expression of the Angiotensinogen Gene and Induction of Hypertrophy in Rat Kidney Proximal Tubular Cells

2001

Shao-Ling Zhang
Catherine To
Xing Chen
János G. Filep
Shiow-Shih Tang
Julie R. Ingelfinger
Serge Carrière
John S.D. Chan

Studies have shown that high levels of glucose and angiotensin II (Ang II) stimulate hypertrophy and the expression of matrix protein genes in mouse proximal tubular cells in vitro. The present study

Keywords:

Angiotensin Receptor Antagonists
Losartan
Angiotensin II
Gene expression
Endocrinology
Internal medicine
Renin–angiotensin system
Angiotensin-converting enzyme
Muscle hypertrophy
Kidney
Biology
Cell
Cell culture

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