Commiphoranes K-O, new terpenoids from Resina Commiphora and their anti-inflammatory activities.

Commiphorane K ( 1 ), a new dinorditerpenoid, commiphoranes L-N ( 2 - 4 ), three new gremacrane-type sesquiterpenoids, and commiphorane O ( 5 ), one new guaiane-type sesquiterpenoid were isolated from Resina Commiphora . Their structures were characterized by spectroscopic and computational methods. In particular, the structure of 4  was confirmed by X-ray crystallography. Compounds 1 - 5  were evaluated for their anti-inflammatory activities. The result shows that compound 2  suppresses lipopolysaccharide (LPS)-stimulated production of TNF- α  in RAW264.7 cells in a dose-dependent manner.