A Review of Antipsychotics in the Treatment of Obsessive Compulsive Disorder

RATIONALE Although many individuals with obsessive compulsive disorder (OCD) show significant improvement after treatment with serotonin reuptake inhibitors (SRIs), the treatment effect is usually partial and residual symptoms remain in most cases despite continued treatment. The proportion of patients failing to achieve a satisfactory outcome is difficult to define, but may be estimated at approximately 40% of cases. Even after switching to a second SRI, approximately