Polymorphism and Forensic Application Value of 71 Y-SNP Loci in Han Population of Northwest China.

OBJECTIVES: To analyze the polymorphism of 71 SNP loci on Y chromosome in Han population of Northwest China, to assess its forensic application value, and to screen out Y-SNP loci for forensic examination of Han population in East, South, and Northwest China based on the integration of previous research results. METHODS: Multiplex polymerase chain reaction （PCR） and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry （MALDI-TOF-MS） were performed on 71 Y-SNP loci of 202 unrelated Han male individuals in Northwest China. Gene diversity （GD） and haplotype diversity （HD） values were calculated, and then Y-SNP loci of Han population in East, South, and Northwest China were screened with the combination of data from previous research. RESULTS: Among the detected 71 loci, 67 loci were polymorphic in the Northwest Han male population, with GD values 0.010 0-0.502 2. There were 22 and 25 loci with a moderate （0.2≤GD<0.3） and high （GD≥0.3） amount of genetic information, respectively. There were 26 loci for the Han communities in Northwest, South, and East China. 结果: 在所检测的71个位点中，有67个位点在西北汉族男性人群中呈多态性分布，GD值在0.010 0~0.502 2，中度信息量（0.2≤GD<0.3）的位点有22个，高度信息量（GD≥0.3）的位点有25个，同时适用于西北、华南和华东汉族群体的位点有26个。. 结论: Y-SNP位点在亲权鉴定和个体识别中具有应用价值，在判断人群分布及迁移信息方面亦具有潜在的应用价值。. 关键词: 法医遗传学；Y染色体；多态性，单核苷酸；等位基因；汉族.