Índices de resistencia a los antibióticos en aislamientos clínicos en Santo Domingo, Ecuador

Antibiotic resistance (ABR) remains one of the most significant global health concerns to date. ABR in the Americas, specifically, represents one of the highest concerns with regard to types of antibiotic resistance and overall rates. We initiated an analysis of overall rates of ABR from patient collected bacterial isolates in a previously unreported region of rural Ecuador from 2017-2018. 907 total clinical isolates were collected between January 2017 to December 2018 and assessed for resistance to 33 different antibiotic compounds. More than half of the isolates tested were resistant to ampicillin (79.8%), ampicillin/Sulbactam (57.5%), amoxicillin/clavulanic acid (62.6%) on Enterobacteriaceae and oxacillin (55.4%) on Staphylococcus aureus. Across all bacterial isolated from 2017 to 2018, 11 of the 33 antibiotics tested showed a significant increase in resistance. Our analysis identifies evidence of high ABR rates in rural Ecuador, which is likely to be a significant underappreciated contributor to the global persistence of resistant bacterial infections.