A sticky situation: From malaria pre-elimination to gene mutation Glucose-6-Phosphate dehydrogenase deficiency (G6PDd) in Eastern Indonesia

In 2013, 30 000 to 38 000 deaths each year mostly in eastern Indonesia by two dominant species of malaria Plasmodium falciparum 62 % and Plasmodium vivax 33 % with API = 15.6 ‰. MoH Republic Indonesia announced to reach the pre-elimination stage for eastern Indonesia. Primaquine is a key drug for the pre-elimination stage. However, primaquine can trig acute hemolysis for people with Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd). This study will assess the prevalence G6PDd, variant gene mutation and whether eastern Indonesia should proceed with the activities of malaria pre-elimination. A survey 555 people enrolled by systematic sampling. Data collected by standard questionnaire, physical examination and laboratory tests (Hb, microscopic, nested PCR and DNA sequencing). Confirmed cases of malaria and G6PDd were map using ArcGIS V.9.1 and SatScan analysis. Statistical analysis by univariate, bivariate and multivariate with α = 0.05 and 95 % confidence interval. This study result, positive number of m...