The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study
2017
The adipocytokines and insulin-like growth factor 1 (IGF-1) are involved in insulin resistance, the
cardiometabolic syndrome, and atherosclerosis. Therefore, investigating the relationship between circulating
levels of the novel adipocytokines and IGF-1 is worthwhile. The correlation between IGF-1,
visfatin, and omentin-1 has not been adequately investigated. In a population-based study, 324 postmenopausal
women were randomly selected. Circulating IGF-1, visfatin, omentin-1, adiponectin, and
high-sensitivity C-reactive protein (hs-CRP) levels weremeasured with the highly specific enzyme-linked
immunosorbent assay method. In multiple regression analyses adjusted for alkaline phosphatase,
osteocalcin, and hs-CRP, circulating IGF-1 was significantly correlated with visfatin levels (standardized
β coefficient [β] = 0.13, partial correlation coefficient [r] = 0.12, p = 0.028). The significant positive
correlation between serum IGF-1 and visfatin levels remained after additional adjustments for age and
BMI (β = 0.12, r = 0.12, p = 0.025), metabolic syndrome (β = 0.13, r = 0.12, p = 0.021), and type 2 diabetes
mellitus (β = 0.13, r = 0.12, p = 0.026). No significant correlationswere found between IGF-1, adiponectin,
and omentin-1. There is a significant correlation between serum IGF-1 and visfatin levels in postmenopausalwomen
beyondmetabolic syndrome, type 2 diabetes, bone formationmarkers, and hs-CRP levels.
The observed correlation between higher circulating IGF-1 and the higher visfatin levels might be a
physiological compensation and adaptation to protect against visfatin-induced proinflammatory effects.
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